"Relaxed" DNA may contribute to aging

From an article in the AAAS (Science):   People with Werner syndrome—a rare disease with symptoms that mimic premature aging—usually go gray in their 20s, develop cataracts and osteoporosis in their 30s, and die before 60. Now, researchers have for the first time created a key class of versatile stem cells that carry the genetic defect that causes the condition. Their analysis suggests that loosely wrapped DNA underlies the accelerated physical decline of Werner syndrome and promotes aging in the rest of the population.   Read more....